Cow's Milk Allergy & Feeding Intolerance Clinical Research

Resources about food allergies in infants and kids.

Alimentum® Clinical Research Study: Growth, Tolerance, and Compliance

A research study showed that Alimentum, the first and only hypoallergenic, extensively hydrolyzed protein-based infant formula with 2'-FL HMO, was well-tolerated by babies and supported growth.

Ramirez-Farias C, Baggs GE, Marriage BJ. Nutrients. 2021;13:186. doi.org/10.3390/nu13010186

Expert Panel: The Beneficial Effects of HMOs in Early Life

This review by pediatric gastroenterology and allergy-immunology experts addressed the bioactive components of human milk, the structure and roles of HMOs, and potential benefits of HMO-supplemented infant formula—particularly for children with cow's milk protein allergy (see methods section).

Sekerel BE, Bingol G, Cullu Cokugras F, et al. J Asthma Allergy. 2021;14:1147-1164. Published 2021 Sep 24. doi:10.2147/JAA.S323734

Cow's Milk Allergy

This review article provides insights on the dietary management of cow's milk allergy.

Arasi S, Cafarotti A, Fiocchi A. Curr Opin Allergy Clin Immunol. 2022;22(3):181-187. doi:10.1097/ACI.0000000000000823

New Insights in Cow's Milk and Allergy: Is the Gut Microbiota the Missing Link?

Though the precise mechanism of the synbiotic effects remains unclear, a recent systematic review and meta-analysis showed amino acid formulas containing synbiotics improved clinical symptoms, allergenicity, rates of infection and hospitalization, and medication usage.

Verduci E, Zuccotti GV, Peroni DG. Nutrients. 2022;14(8):1631. Published 2022 Apr 14. doi.org/10.3390/nu14081631

Double-Blinded, Placebo-Controlled, Food Challenges (DBPCFC) of a Strong-Tasting Food: Lessons Learned

A poster presentation of findings from a double-blind, placebo-controlled, food challenges (DBPCFC) study of hypoallergenic formula in allergic patients.

Borschel M, Burks WA. Double-blind, placebo-controlled, food challenges (DBPCFC) of a strong tasting food: lessons learned. Clinical and Translational Allergy. 2014;4(Suppl 1):P95.

The Jejunal Absorption of Glucose Oligomers in the Absence of Pancreatic Enzymes

A comparison study on the absorption of carbohydrate from solutions of sucrose and glucose oligomers (GO) in the absence of pancreatic secretions.

Kerzner, B., Sloan, H. R., Haase, G., McClung, H. J., & Ailabouni, A. H. (1981). The jejunal absorption of glucose oligomers in the absence of pancreatic enzymes. Pediatric Research, 15 (3), 250–253. https://doi.org/10.1203/00006450-198103000-00010

Safety of Casein Hydrolysate Formula In Children With Cow's Milk Allergy

A study of Similac® Alimentum®, a casein hydrolysate infant formula, evaluating if it can be administered safely to children with cow's milk hypersensitivity.

Sampson, H. A., Bernhisel-Broadbent, J., Yang, E., & Scanlon, S. M. (1991). Safety of casein hydrolysate formula in children with cow milk allergy. The Journal of Pediatrics, 118 (4 Pt 1), 520–525. https://doi.org/10.1016/s0022-3476(05)90001-2

Hypoallergenicity and Efficacy of an Amino Acid–Based Formula in Children with Cow’s Milk and Multiple Food Hypersensitivities
A feeding study to determine the hypoallergenicity of a pediatric formula by evaluating growth, tolerance, and biochemical response.
Sicherer, S. H., Noone, S. A., Koerner, C. B., Christie, L., Burks, A. W., & Sampson, H. A. (2001). Hypoallergenicity and efficacy of an amino acid-based formula in children with cow's milk and multiple food hypersensitivities. The Journal of Pediatrics, 138(5), 688–693. https://doi.org/10.1067/mpd.2001.113007
Lactose-Free Milk Protein-Based Infant Formula: Impact on Growth and Gastrointestinal Tolerance in Infants

A prospective, blinded, randomized clinical trial in normal-term infants of a lactose-free milk protein-based formula versus a standard commercial lactose containing milk-based formula.

Lasekan, J. B., Jacobs, J., Reisinger, K. S., Montalto, M. B., Frantz, M. P., & Blatter, M. M. (2011). Lactose-free milk protein-based infant formula: impact on growth and gastrointestinal tolerance in infants. Clinical Pediatrics, 50(4), 330–337. https://doi.org/10.1177/0009922810390511

Milk Protein-Based Infant Formula Containing Rice Starch and Low Lactose Reduces Common Regurgitation in Healthy Term Infants: A Randomized, Blinded, and Prospective Trial

A study evaluating growth, gastrointestinal tolerance, and efficacy with the goal of reducing common spit-up in normal, healthy term infants fed a rice starch pre-thickened lactose-free milk protein-based infant formula.

Lasekan, J. B., Linke, H. K., Oliver, J. S., Carver, J. D., Blatter, M. M., Kuchan, M. J., Cramer, J. M., & Pollack, P. F. (2014). Milk protein-based infant formula containing rice starch and low lactose reduces common regurgitation in healthy term infants: a randomized, blinded, and prospective trial. Journal of the American College of Nutrition, 33(2), 136–146. https://doi.org/10.1080/07315724.2013.828578
Efficacy of Soy-Based Formulas in Alleviating Gastrointestinal Symptoms in Infants With Milk-Based Formula Intolerance: A Randomized Clinical Trial

A clinical study assessing gastrointestinal (GI) tolerance in healthy, full-term infants whose pediatricians recommended a formula change due to perceived cow's milk formula intolerance.

Lasekan, J. B., & Baggs, G. E. (2021). Efficacy of Soy-Based Formulas in Alleviating Gastrointestinal Symptoms in Infants With Milk-Based Formula Intolerance: A Randomized Clinical Trial. Clinical Pediatrics, 60(3), 184–192. https://doi.org/10.1177/0009922820973017

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