Cow's Milk Allergy In Infants

Milk protein allergy is a recognized problem in an infant's first year of life. Cow’s milk protein allergy is the most common such allergy and a common condition encountered in children with incidence estimated as 2% to 7.5% in the first year of life.1 Diagnosis is suspected on history alone, with laboratory evaluations playing a supporting role. Confirmation requires elimination and reintroduction of the suspected allergen. Management includes diet modification for nursing mothers and hydrolyzed formulas for formula-fed infants. Assessing the underlying immunopathology can aid in determining prognosis.


Related Education for Professionals

A Review of the Immune Benefits of 2’-Fucosyllactose Human Milk Oligosaccharide and Pre-clinical Evidence of Its Effects on Food Allergies

A course that reviews the emerging role of the human milk oligosaccharide, 2'-fucosyllactose (2'-FL) in allergy modulation; discusses 2'-FL potential mechanisms of action; and recognizes the importance of breastfeeding. Originally presented from Abbott Nutrition Health Institute (ANHI) on June 6, 2019 at the ESPGHAN Conference in Glasgow, Scotland.

Immune Dysregulation in Allergy

In this video that was originally presented from ANHI, professor Loscher discusses normal immune development in infants; reviews the dysregulation in the immune system that results in allergic responses; describes how we can manipulate the immune system to overcome this dysregulation; and explains the differences between breastfed and bottle-fed infants.

Clinical Presentations of Cow's Milk Allergy in Infants and Children

In this course that was originally presented from ANHI, cow’s milk allergy (CMA) is defined; its clinical features are discussed; dietary management is reviewed; and case-study presentations are reviewed.


Related Clinical Research

Alimentum Clinical Research Study: Growth Tolerance and Compliance

A research study showing that Alimentum, the first and only hypoallergenic extensively hydrolyzed protein infant formula with 2'-FL HMO, was well tolerated by babies and supported normal growth.

Ramirez-Farias C, Baggs GE & Marriage BJ. Nutrients. 2021;13:186.

Safety of Casein Hydrolysate Formula In Children With Cow Milk Allergy

A study of Alimentum, a casein hydrolysate infant formula, evaluating if it can be administered safely to children with cow milk hypersensitivity.

Sampson, HA, Bernhisel-Broadbent, J, Yang, E, & Scanlon, SM. Safety of casein hydrolysate formula in children with cow milk allergy. The Journal of Pediatrics. 1991;118(4 Pt 1), 520–525.

Hypoallergenicity and efficacy of an amino acid–based formula in children with cow’s milk and multiple food hypersensitivities

A feeding study to determine the hypoallergenicity of a pediatric formula by evaluating growth, tolerance, and biochemical response.

Sicherer, SH, Noone, SA, Koerner, CB, Christie, L, Burks, AW, & Sampson, HA. Hypoallergenicity and efficacy of an amino acid-based formula in children with cow's milk and multiple food hypersensitivities. The Journal of Pediatrics. 2001;138(5), 688–693.


Related Nutrition Resources

Clinical Support for Similac Alimentum

Similac Alimentum formula has a unique dual-carbohydrate blend to help maximize absorption.

Similac Alimentum

WIC eligible in all 50 states.*

* WIC is a service mark of the US Department of Agriculture, and an abbreviation for the Special Supplemental Nutrition Program for Women, Infants, and Children. No endorsement of any brand or product by the USDA is implied or intended. Requires state medical documentation form. State approval is subject to change.


Product Solutions

Similac® Alimentum®

A 20 Cal/fl oz., nutritionally complete, hypoallergenic formula for infants, including those with colic symptoms due to protein sensitivity, severe food allergies, sensitivity to intact protein, protein maldigestion, or fat malabsorption. Appropriate supplemental beverage for children with severe food allergies, sensitivity to intact protein, protein maldigestion, or fat malabsorption.

Similac Pro-Sensitive®

A 20 Cal/ fl oz., nutritionally complete, non-GMO*, iron-fortified infant formula designed for use as a milk-based alternative to standard milk-based formulas for sensitive tummies. Designed to support both immune and cognitive development with key ingredients found in breast milk. Suitable for infants with lactose sensitivity.

* Ingredients not genetically engineered
† Typical Value 0.1 g lactose/ 100 kcal compared to Similac Advance (11g lactose/ 100kcal).

Similac Pro-Total Comfort®

A gentle formula with 2'-FL HMO for immune support, Similac Pro-Total Comfort is a nutritionally complete infant formula that has partially hydrolyzed whey protein as an alternative to standard intact-protein milk-based formulas. After switching to Pro-Total Comfort, parents reported a significant reduction in fussiness, gas, and crying after just 1 day of feeding.

Similac® Soy Isomil®

A 20 Cal/fl oz, nutritionally complete, soy-based infant formula for infants with feeding problems such as fussiness and gas; for infants whose parents choose a milk-free formula as a first feeding or as a supplement to breastfeeding; and for infants of vegetarian families.  A lactose-free feeding for patients with disorders for which lactose should be avoided, including lactase deficiency, lactose intolerance, and galactosemia.


Connect With Your Patients

For Patients - Cow's Milk Allergy (CMA) Infographic

Globally, approximately 2.5% of babies develop cow’s milk allergy in their first year of life. Use this infographic to teach parents and caregivers how to keep their dairy-allergic children safe as they grow and develop.

Similac Alimentum Patient Brochure

A patient brochure explaining the benefits of feeding an infant Alimentum and its participation in WIC. 

References: 1. Mousan G, et al. Clin Pediatr (Phila). 2016 Oct;55(11):1054-63. doi: 10.1177/0009922816664512