Feeding Intolerance

Feeding intolerance can be manifested by nuisance symptoms such as abdominal distension, gassiness, fussiness, and/or spit-up…or more severe symptoms such as rash, wheezing, eczema, vomiting, and/or diarrhea. Feeding intolerance in infancy – whether benign or serious – often results in a change in feedings. At its worst, feeding intolerance and its treatment attempts may lead to delayed attainment of full oral feedings, suboptimal nutrition, and/or prolonged parenteral nutrition.

Related Clinical Research

Safety of Casein Hydrolysate Formula In Children With Cow Milk Allergy

A study of Similac® Alimentum®, a casein hydrolysate infant formula, evaluating if it can be administered safely to children with cow milk hypersensitivity.

Sampson, HA, Bernhisel-Broadbent, J, Yang, E, & Scanlon, SM. Safety of casein hydrolysate formula in children with cow milk allergy. The Journal of Pediatrics. 1991;118(4 Pt 1), 520–525. https://doi.org/10.1016/s0022-3476(05)90001-2

 
Milk Protein-Based Infant Formula Containing Rice Starch and Low Lactose Reduces Common Regurgitation in Healthy Term Infants: A Randomized, Blinded, and Prospective Trial

A study evaluating growth, gastrointestinal tolerance, and efficacy with the goal of reducing common spit-up in normal, healthy term infants fed a rice starch pre-thickened lactose-free milk protein-based infant formula.

Lasekan, JB, Linke, HK, Oliver, JS, Carver, JD, Blatter, MM, Kuchan, MJ, Cramer, JM, & Pollack, PF. Milk protein-based infant formula containing rice starch and low lactose reduces common regurgitation in healthy term infants: a randomized, blinded, and prospective trial. Journal of the American College of Nutrition. 2014;33(2), 136–146. https://doi.org/10.1080/07315724.2013.828578

Lactose-Free Milk Protein-Based Infant Formula: Impact on Growth and Gastrointestinal Tolerance in Infants

A prospective, blinded, randomized clinical trial in normal-term infants of a lactose-free milk protein-based formula versus a standard commercial lactose-containing milk-based formula.

Lasekan, JB, Jacobs, J, Reisinger, KS, Montalto, MB, Frantz, MP, & Blatter, MM. Lactose-free milk protein-based infant formula: impact on growth and gastrointestinal tolerance in infants. Clinical Pediatrics. 2011;50(4), 330–337. https://doi.org/10.1177/0009922810390511

 

Efficacy of Soy-Based Formulas in Alleviating Gastrointestinal Symptoms in Infants With Milk-Based Formula Intolerance: A Randomized Clinical Trial

A clinical study assessing gastrointestinal (GI) tolerance in healthy, full-term infants whose pediatricians recommended a formula change due to perceived cow's milk formula intolerance.

Lasekan, JB, & Baggs, GE. Efficacy of Soy-Based Formulas in Alleviating Gastrointestinal Symptoms in Infants With Milk-Based Formula Intolerance: A Randomized Clinical Trial. Clinical Pediatrics. 2021;60(3), 184–192. https://doi.org/10.1177/0009922820973017

 
 

Related Nutrition Resources

Similac Office Custom Feeding Spectrum

An overview of products within the Similac custom feeding system that support preterm and term infant feeding.

Clinical Support for Similac Alimentum

Similac Alimentum formula has a unique dual-carbohydrate blend to help maximize absorption.

 
 

Product Solutions

Similac® 360 Total Care®

Similac 360 Total Care* Infant Formula is made with an exclusive blend of 5 HMO prebiotics structurally identical to those in breast milk. Our formula also has nutrition designed for immune support, brain development, and digestive health. Similac is the #1 infant formula brand chosen by parents. Our formula contains no artificial growth hormones and is non-GMO.§

* Not for infants or children with galactosemia.
 Total US infant formula, all outlets as of 9/1/2021, Nielsen data.
 No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
§ Ingredients not genetically engineered.

Similac® 360 Total Care® Sensitive

Similac 360 Total Care Sensitive* Infant Formula is gentle nutrition designed to ease common tummy troubles like fussiness and gas due to lactose sensitivity. Our formula has an exclusive blend of 5 HMO prebiotics structurally identical to those in breast milk, and nutrition designed for immune support, brain development, and digestive health. Similac is the #1 infant formula brand chosen by parents. Our formula has no artificial growth hormones and is non-GMO.§

* Not for infants or children with galactosemia.
 Total US infant formula, all outlets as of 9/1/2021, Nielsen data.
 No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
§ Ingredients not genetically engineered.

Similac Pro-Sensitive®

A 20 Cal/ fl oz, nutritionally complete, non-GMO*, iron-fortified infant formula designed for use as a milk-based alternative to standard milk-based formulas for sensitive tummies. Designed to support both immune and cognitive development with key ingredients found in breast milk. Suitable for infants with lactose sensitivity.†

* Ingredients not genetically engineered
† Typical Value 0.1 g lactose/ 100 kcal compared to Similac Advance (11g lactose/ 100kcal).

Similac Pro-Total Comfort®

A gentle formula with 2'-FL HMO for immune support, Similac Pro-Total Comfort is a nutritionally complete infant formula that has partially hydrolyzed whey protein as an alternative to standard intact-protein milk-based formulas. After switching to Pro-Total Comfort, parents reported a significant reduction in fussiness, gas, and crying after just 1 day of feeding.

Similac® Alimentum®

A 20 Cal/fl oz., nutritionally complete, hypoallergenic formula for infants, including those with colic symptoms due to protein sensitivity, severe food allergies, sensitivity to intact protein, protein maldigestion, or fat malabsorption. Appropriate supplemental beverage for children with severe food allergies, sensitivity to intact protein, protein maldigestion, or fat malabsorption.

Similac Soy Isomil®

A 20 Cal/fl oz, nutritionally complete, soy-based infant formula for infants with feeding problems such as fussiness and gas; for infants whose parents choose a milk-free formula as a first feeding or as a supplement to breastfeeding; and for infants of vegetarian families.  A lactose-free feeding for patients with disorders for which lactose should be avoided, including lactase deficiency, lactose intolerance, and galactosemia.

 
 

Connect With Your Patients

For Patients - Cow's Milk Allergy (CMA) Infographic

Globally, approximately 2.5% of babies develop cow’s milk allergy in their first year of life. Use this infographic to teach parents and caregivers how to keep their dairy-allergic children safe as they grow and develop.

Similac Alimentum Brochure

Alimentum patient information explaining product benefits and that it is WIC-eligible.