Growth & Undernutrition – Infant Clinical Research

Studies analyzing challenges surrounding term infant growth and development.

Shifts in the Distribution of Births by Gestational Age

The National Vital Statistics System released this article describing a shift toward shorter gestational ages in the US from 2014-2022, during which the rate of full-term and late/post-term births declined by 6% and 28%, respectively. Learn more about the methods and potential implications of this study.

Martin JA, Osterman MJK. Natl Vital Stat Rep. 2024;73(1):1-11.

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Infant Nutrition Requirements and Options

Get insight into the nutrition needs of infants and the role a team of healthcare professionals may play to evaluate and improve care.

Patel JK, Rouster AS. Infant Nutrition Requirements and Options. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 8, 2023.

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Infants Fed Breast Milk or 2'-FL-Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids

Read the results of a clinical study on the effects of feeding formulas supplemented with the HMO 2'-fucosyllactose (2'-FL) on serum metabolite levels compared to breastfed infants.

Hill DR, Buck RH. Nutrients. 2023;15(10):2339. Published 2023 May 17. doi:10.3390/nu15102339

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Impact of RSV on Child, Caregiver, and Family Quality of Life (QOL)

Data on US children's QOL with respiratory syncytial virus (RSV) is scarce and doesn't consider healthy children born at term. This analysis determined that more QOL studies are needed beyond hospitalized premature infants.

Glaser EL, Hariharan D, Bowser DM, et al. J Infect Dis. 2022;226(Suppl 2):S236-S245. doi:10.1093/infdis/jiac183

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Clinical Studies on the Supplementation of HMOs

These studies evaluated the health outcomes of published clinical trials involving the supplementation of HMOs. They consistently found that HMO supplementation was safe and well-tolerated.

Schönknecht YB, Moreno Tovar MV, Jensen SR, Parschat K. Nutrients. 2023;15(16):3622. Published 2023 Aug 17. doi:10.3390/nu15163622

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Challenges For The Newborn Following Influenza Virus Infection

This review summarizes the challenges newborns' immune systems experience fighting influenza virus and opportunities for developing vaccines.

Alexander-Miller MA. Front Immunol. 2020;11:568651. Published 2020 Sep 16. doi:10.3389/fimmu.2020.568651

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RSV Disease in Infants: Can We See a Brighter Future?

Respiratory syncytial virus (RSV) has been identified as a major global priority; however, preventative measures for infants worldwide have yet to be implemented. New technologies could help address the leading cause of hospitalization in infants.

Baraldi E, Checcucci Lisi G, Costantino C, et al. Hum Vaccin Immunother. 2022;18(4):2079322. doi:10.1080/21645515.2022.2079322

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Catch-Up Growth in Infants & Young Children With Faltering Growth (FG): Expert Opinion to Guide General Clinicians

This study reports practical recommendations for general clinicians on how FG should be defined in different young child populations at risk, how FG should be assessed and managed, and the role of catch-up growth after a period of FG.

Cooke R, Goulet O, Huysentruyt K, et al. J Pediatr Gastroenterol Nutr. 2023;77(1):7-15. doi:10.1097/MPG.0000000000003784

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Pediatric Malnutrition Screening Tools

Nutrition screening tools have been developed for pediatric patients to help facilitate the identification of kids at risk for malnutrition. This review provided an overview of recent progress in screening methods.

Hulst JM, Huysentruyt K, Joosten KF. Curr Opin Clin Nutr Metab Care. 2020;23(3):203-209. doi:10.1097/MCO.0000000000000644

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The Burden of Respiratory Syncytial Virus (RSV) Infection During Baby's First Year

A study of infants who developed RSV in the first year of life: incidence, hospitalization, treatment, and concurrent acute otitis media.

Thomas E, Mattila JM, Lehtinen P, Vuorinen T, Waris M, Heikkinen T. J Infect Dis. 2021;223(5):811-817. doi:10.1093/infdis/jiaa754

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The Role of Nutrition in Brain Development: The Golden Opportunity of the "First 1000 Days"

This article focused on brain development in late fetal and early postnatal life. Evidence presented showed how nutrition can support optimal brain development before the age of 3 years.

Cusick SE, Georgieff MK. J Pediatr. 2016;175:16-21. doi:10.1016/j.jpeds.2016.05.013

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SARS-CoV-2 Exposure from Healthcare Workers to Infants

This study evaluated the risk and outcomes of SARS-CoV-2 transmission from positive healthcare workers to infants in the NICU and the postnatal ward.

Shaiba LA, Hadid A, Abdulghani SH, Hussain SA, Shah PS. [published online August 27, 2021]. Am J Perinatol. 2021;10.1055/s-0041-1735215. doi:10.1055/s-0041-1735215

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