Flexible, Science-Based Solutions to Meet the Needs of Your Patients

Customizable Solutions for Individualized Outcomes

The Similac® Liqui-Mix® System and Liquid Protein Fortifier can be used to customize calories and protein in an all-liquid solution.

SIMILAC LIQUI-MIX SYSTEM 

  • All-liquid solution eliminates the need for most powder mixing 

  • Easy to customize feedings, including 20, 24, 26, 27, and 28 cal/fl oz

  • Easy to customize protein levels with Liquid Protein Fortifier

SIMILAC® NEOSURE® 

Nutrient-enriched* preterm post-discharge formula shown to improve overall growth1

CLINICALLY PROVEN SIMILAC® HUMAN MILK FORTIFIER HYDROLYZED PROTEIN CONCENTRATED LIQUID (HMF HP CL)

THE FIRST HUMAN MILK FORTIFIER WITH EXTENSIVELY HYDROLYZED PROTEIN

Supported by 5 clinical studies, our human milk fortifier has been shown to deliver excellent outcomes.2-6 

IMPROVED TOLERANCE3,4,6

IMPROVED BLOOD UREA NITROGEN (BUN) LEVELS2,4

IMPROVED WEIGHT GAIN2-4,6,‡

FEWER ADVERSE EVENTS AND/OR LESS ACIDOSIS3-6

SAFE HANDLING AND USE

  • Packaged in single-use, ready-to-use packets for precise dosing and nutrient delivery 

  • Liquid form reduces the risk for environmental contamination 

  • Packets allow for aseptic handling when used as directed

  • Developed with a focus on safe handling for NICU use 

KEY CLINICAL STUDY SHOWS IMPORTANT GAINS IN GROWTH7

Similac® offers the FIRST nonacidified human milk fortifier that has extensively hydrolyzed protein.

  • Similac HMF HP CL infants gained 0.5 lb more weight at study day 29, and both groups increased in weight and length over time 

  • Similac HMF HP CL delivers 4.3g§ of protein (g/kg/day)

Evaluable patients (n = 75).

Hash marks indicate standard error. 

ǁ Weight, g. Repeated Measures Analysis main effect, P = 0.036; post-hoc per timepoint analysis: SDAY 29, P = 0.024. Length, cm. Repeated Measures Analysis main effect, P = 0.029; post-hoc per timepoint analysis: SDAY 22, P = 0.006, SDAY 29, P = 0.037.

¶ These infants strictly adhered to study protocol and received ≥95% of their total intake from human milk with their assigned study fortifier. 

FEATURES OF SIMILAC HMF HP CL

  • Extensively hydrolyzed protein source to help promote easy digestion

  • Has OptiGRO® for brain and eye development 

  • Low iron level provides flexibility to add iron as needed

KEY CLINICAL STUDY SHOWS TOLERANCE7

Well tolerated 

  • Only 1 in 66 (1.5%) NICU patients in the Similac HMF HP CL group discontinued due to feeding intolerance 

  • No incidence of metabolic acidosis with infants fed Similac HMF HP CL or control  
     

Improved protein status 

  • Recent studies have identified BUN levels of >9 mg/dL as an indicator of protein sufficiency in preterm infants8-10 

  • BUN levels remained above 9 mg/dL in preterm infants receiving Similac HMF HP CL

     

Mean BUN levels

EFFECTS OF AN ACIDIC pH ON HUMAN MILK

In vitro study of human milk acidified with citric acid to a pH of 4.511

Similac HMF retains the pH of human milk to near neutral range, which should preserve the unique benefits of human milk.

* Increased protein, vitamins, and minerals compared to term infant formula.
† Launched in 2014. First nonacidified human milk fortifier that is hydrolyzed.
‡ In the Schanler study, weight gain was improved SDAY1-SDAY15.
§ Composition of human milk-based feedings at 120 kcal/kg and 24 Cal/fl oz. 

References: 1. Carver JD, et al. Pediatrics. 2001;107(4):683-689. 2. Kim J, et al. J Pediatr Gastroenterol Nutr. 2015;61(6):665-671. 3. Kumar N, et al. Am J Perinatol. 2017;34(14):1411-1416. 4. Schanler RJ, et al. J Pediatr. 2018;202:31-37.e2. 5. Lainwala S, et al. J Neonatal Perinatal Med. 2017;10(4):393-401. 6. Clark B, et al. J Acad Nutr Diet. 2017;117(9 suppl 1):A11. 7. Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61(6):605-671. 8. Arslanoglu S, et al. J Perinatol. 2006;26:614-621. 9. Alan S, et al. Early Hum Dev. 2013;89:1017-1023. 10. Ergenekon E, et al. Turk J Pediatr. 2013;55:365-370. 11. Erickson T, et al. J Perinatol. 2013;33:371-373.