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Liqui-Mix® System: Human Milk Fortification

Similac® Special Care® Liquid Formulas and Similac® Human Milk Fortifier Hydrolyzed Protein Concentrated Liquid


Eliminate most powder mixing—the AND and the CDC* recommend that powdered infant formulas not be used in the NICU unless there is no nutritionally appropriate alternative available.1,2 The Liqui-Mix System provides an all-liquid solution to deliver a high-calorie, nutrient-dense feeding.

  • NICU babies are often immunocompromised and may be at high risk for developing infections
  • Powdered formulas are not commercially sterile 
  • The addition of powdered infant formula to human milk to achieve higher caloric densities does not meet the protein or micronutrient needs of hospitalized or discharged preterm infants

Similac Special Care liquid formulas and Similac Human Milk Fortifier Hydrolyzed Protein Concentrated Liquid eliminate the need for most powder mixing.


All liquid

  • Liquid formulas and concentrated liquid human milk fortifiers eliminate the need for most powder mixing and meet the AND & CDC recommendations to reduce risk of contamination.


  • Easy mixing to create a variety of calorically dense feedings


  • Easy to use 2:1, 1:1, 1:2 system (refer to recipes below)

Examples of recipe system:

  • To make Fortified Human Milk (FHM) 26 Cal/fl oz, mix 2 parts FHM + 1 part Similac Special Care 30 (SSC 30), one example is to mix 60 mL FHM + 30 mL SSC 30.

  • To make FHM 27 Cal/fl oz, mix 1 part FHM + 1 part SSC 30, one example is to mix 30 mL FHM + 30 mL SSC 30.

  • To make FHM 28 Cal/fl oz, mix 1 part FHM + 2 part SSC 30, one example is to mix 30 mL FHM + 60 mL SSC 30.

NOTE: Proper hygiene, handling, and storage are important when preparing infant feedings. Always follow your hospital’s policies and procedures regarding safe handling practices when preparing infant feedings to prevent the possibility of contamination.


* Academy of Nutrition and Dietetics and Centers for Disease Control and Prevention.

† Life Sciences Research Office recommendations for preterm and low-birth-weight infants.5 Visit http://www.lsro.org/articles/lowbirthweight_rpt.pdf for a summary of the report. NOTE: These guidelines are designed for preterm infant formulas, NOT fortified human milk. Thus, these recommendations can serve only as a general guideline relative to fortified human milk.

‡ The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable. Therefore, actual nutrient levels may be higher or lower than the levels listed. Human milk values were obtained from: Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, OH: Abbott Nutrition, Abbott Laboratories, January 1998.

§ When combined with human milk, does not increase concentration of nutrients to levels achieved with Similac Human Milk Fortifier. 

References: 1. Pediatric Nutrition Practice Group, Steele C, Collins E, eds. Infant and Pediatric Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 3rd Edition. Chicago: Academy of Nutrition and Dietetics. 2019, P. 12. 2. Centers for Disease Control and Prevention, Enterobacter sakazakii infections associated with the use of powdered infant formula—Tennessee, 2001. Available at http://www.cdc.gov/mmwr/ preview/mmwrhtml/mm5114a1.htm. Accessed November 27, 2019. 3. Groh-Wargo S, Thompson M. Managing the human-milk-fed, preterm, VLBW infant at NICU discharge: the sprinkles dilemma. Infant, Child & Adolesc Nutr. 2014;6(5):262-265. 4. Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998. 5. Klein CJ. J Nutr. 2002;132:1395S-1577S.




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