Liquid Protein Fortifier 

Designed to Provide the Individual Protein Needs of Premature Infants

Mixing Instructions

Must be mixed with human milk, fortified human milk, or formula before feeding.

  • Use as directed by a healthcare professional.
  • Do not add water. Shake gently.
  • Do not use if breakaway ring is missing or broken.
  • The health of the infant depends on carefully following the directions for preparation and use. Proper hygiene, handling, and storage are important when preparing infant feedings. 

Directions for Preparation and Use 

Mixing Instruction Illustrations Mixing Instruction Illustrations
  1. Twist off cap.
  2. Pour Liquid Protein Fortifier into medicine cup.1
  3. Draw up volume specified by a healthcare professional into a single-use oral syringe.1
  4. Dispense into measured human milk or formula and swirl. Pour desired amount of mixture into feeding container.


  • Store unopened at room temperature; avoid extreme temperatures.
  • Fortifier: Refrigerate after opening; use within 72 hours or discard.
  • Fortified human milk or formula: Once mixed, refrigerate and use within 24 hours or discard.

Mixing Worksheet

Recommended protein intake

  • Expert guidelines recommend a range of 3.0–4.3 g/kg/day2-6

Protein intake from preterm human milk

  • Varies 1.5–2.96 g/kg/day7

How to calculate how much Liquid Protein Fortifier is needed for preterm infant feedings:

Mixing Instructions Formula Mixing Instructions Formula

References: 1. Robbins ST, et al. Formula preparation and handling. In: Infant Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd ed. Chicago, IL: American Dietetic Association; 2011:80. 2. Klein CJ. J Nutr. 2002;132(6, suppl 1):1395S-1577S. 3. American Academy of Pediatrics, Committee on Nutrition. Nutritional needs of the preterm infant. In: Kleinman RE, Greer FR, eds. Pediatric Nutrition. 7th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2014:93. 4. Tsang R, et al. Nutrition of the Preterm Infant: Scientific Basis and Practical Applications. 2nd ed. Cincinnati, OH: Digital Education Publishing; 2005:417. 5. CPS. CMAJ. 1995;152(11):1765-1785. 6. Adamkin D, ed. Nutritional Strategies for the Very Low Birthweight Infant. New York, NY: Cambridge University Press; 2009:107. 7. Corvaglia L, et al. Early Hum Dev. 2010;86(4):237-240.