Similac® 360 Total Care®
Similac 360 Total Care is the only infant formula brand to have our unique blend of 5 HMOs.
The largest and longest US study evaluating infant formula with HMOs.*
* A clinical study through 12 months of age that enrolled 607 infants fed Similac 360 Total Care, formula without HMOs, or breast milk in the US (Reverri et al. 2024, Reverri et al. 2025).
Similac 360 Total Care to support 360 baby development
New Clinical Study: 5 HMOs & 5 Clinically Shown Benefits†
Normal Growth
Growth like that of breastfed infants‡:
• Weight
• Length
• Weight-for-Length
• Head Circumference
Brain Development
Infants fed Similac 360 Total Care had clinically shown results in language and social development like breastfed infants at 12 months of age.§
Tolerance
Clinically shown to be well-tolerated.ǁ
Gut Health
Infants fed Similac 360 Total Care had increased growth of beneficial gut bacteria.¶
Immune Support
Similac 360 Total Care with 5 HMOs has been clinically shown to positively impact the developing immune system.#
† In infants fed Similac 360 Total Care at or during the first 6 months of age and cognition at 12 months of age. Brain development refers to clinically shown benefits in language and social development like breastfed babies (Reverri et al. 2024, Reverri et al. 2025, Niemiro et al. 2025).
‡ In a clinical study at 6 months of age, growth among infants fed Similac 360 Total Care, formula without HMOs, or breast milk was not significantly different (Reverri et al. 2024).
§ Measured by parent-reported MacArthur-Bates Communicative Development Inventories (Phrases Understood, Imitation when Starting to Talk) and Bayley Scales of Infant and Toddler Development (Adaptive Behavior, Socialization, Interpersonal Relationships, and Play and Leisure Scores) (Reverri et al. 2025).
|| In a clinical study through 6 months of age comparing infants fed Similac 360 Total Care, formula without HMOs, or breast milk (Reverri et al. 2024).
¶ In a clinical study, growth of a group of 5 species of infant-specific Bifidobacterium was like breastfed infants and greater than infants fed a formula without HMOs at 6 months of age (Niemiro et al. 2025).
# As compared to formula without HMOs, at 6 months of age comparing infants fed Similac 360 Total Care, formula without HMOs, or breast milk (Reverri et al. 2024, Niemiro, et al. 2025).
** Measured by parent-reported MacArthur-Bates Communicative Development Inventories (Phrases Understood, Imitation when Starting to Talk) and Bayley Scales of Infant and Toddler Development (Adaptive Behavior, Socialization, Interpersonal Relationships, and Play and Leisure Scores) at 12 months of age; Other cognitive assessment measures were not significantly different among groups; ‘Performance like’ refers to no significant differences in scores; ‘Were developing relationship skills’ is about responding and relating to others (Reverri et al. 2025).
References: 1. Reverri EJ, Oliver JS, Yalawar M, et al. Clinically relevant outcomes in infants fed a formula supplemented with five specific human milk oligosaccharides: a large, randomized, controlled trial. JPGN Reports. 2024; S468, AL51 Data on File. October 2024. Abbott Nutrition, Columbus, OH, AL51 Data on File. November 2024. Abbott Nutrition, Columbus, OH. 2. Reverri EJ, et al. Cognitive outcomes after 12 months of feeding an infant formula with 5 specific human milk oligosaccharides: a large, randomized, controlled trial. JPGN Reports. 2025;6(S1):S1174. Orally presented at the 57th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition; May 15, 2025; Helsinki, Finland. 3. Niemiro G, et al. Infant formula with 5 human milk oligosaccharides promoted a gut microbiome like breastfed infants at 6 months of age. JPGN Reports. 2025;6(S1):S1279.
HMOs May Have Multiple Mechanisms of Action, One of Which is the Gut-Brain Axis.
Recommend Similac 360 Total Care With Our Unique Blend of 5 HMOs
†† Enfamil was not used in the previously mentioned clinical study.
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