Similac Pro-Total Comfort® Powder

Infant formula with iron

Similac Pro-Total Comfort® Powder

Infant formula with iron

Similac Pro-Total Comfort* is a gentle formula with 2'-FL human milk oligosaccharide (2'-FL HMO), an immune-nourishing prebiotic like that found in breast milk that supports baby’s developing immune system. It’s an easy-to-digest formula for babies with fussiness, gas, and crying who have difficulty tolerating other milk-based formulas.

* Not for infants or children with galactosemia.

  • EASY-TO-DIGEST: Partially hydrolyzed whey protein allows for easy digestion; reduced colicky symptoms such as fussiness and gas within one day§
  • GENTLE FORMULA + IMMUNE SUPPORT: Similac Pro-Total Comfort is a gentle formula with 2'-FL HMO, a prebiotic that helps strengthen your baby’s immune system
  • SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA and lutein, ingredients found in breast milk that are important for helping to support baby’s brain and eye development
  • NO PALM OLEIN OIL: Has no palm olein oil to support excellent calcium absorption
  • PREFERRED BRAND: Similac® is the #1 infant formula brand fed in hospitals
  • NO ARTIFICIAL GROWTH HORMONES & NON-GMO: Similac is the first leading infant formula brand with no artificial growth hormones. Similac Pro-Total Comfort contains ingredients that are not genetically engineered.

* Not for infants or children with galactosemia.
Not from human milk.
At significant levels.
§ Parents reported after switching to Similac Pro-Total Comfort.
No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Ingredients not genetically engineered


Your Patient's Sample May Be Provided As A 7-Oz Powder Container Or As A Digital Coupon. 


Clinical Information

Nutritional Information

Unflavored Powder - 100 Cal (5 fl oz, prepared as directed)

Nutrient Data
Amount Per Serving
Calories 100
Volume, mL 148
Protein, g 2.32
Fat, g 5.4
Carbohydrate, g 10.7
Water, g 133
Linoleic Acid, mg 1000
Amount Per Serving
Vitamin A, IU 300
Vitamin D, IU 60
Vitamin E, IU 1.5
Vitamin K, mcg 8
Thiamin (Vitamin B1), mcg 100
Riboflavin (Vitamin B2), mcg 150
Vitamin B6, mcg 60
Vitamin B12, mcg 0.25
Niacin, mcg 1050
Folic Acid (Folacin), mcg 15
Pantothenic Acid, mcg 450
Biotin, mcg 4.4
Vitamin C (Ascorbic Acid), mg 9
Choline, mg 24
Inositol, mg 24
Amount Per Serving
Calcium, mg 105
Calcium, mEq 5.3
Phosphorus, mg 75
Magnesium, mg 6
Iron, mg 1.8
Zinc, mg 0.75
Manganese, mcg 5
Copper, mcg 90
Iodine, mcg 15
Selenium, mcg 2
Sodium, mg 44
Sodium, mEq 1.9
Potassium, mg 118
Potassium, mEq 3
Chloride, mg 65
Chloride, mEq 1.8

Unflavored Powder - 1000 mL (1.1 QT, prepared as directed)

Nutrient Data
Amount Per Serving
Calories 676
Volume, mL 1000
Protein, g 15.68
Fat, g 36.49
Carbohydrate, g 72.3
Water, g 899
Linoleic Acid, mg 6757
Amount Per Serving
Vitamin A, IU 2029
Vitamin D, IU 405
Vitamin E, IU 10.1
Vitamin K, mcg 54.1
Thiamin (Vitamin B1), mcg 676
Riboflavin (Vitamin B2), mcg 1014
Vitamin B6, mcg 405
Vitamin B12, mcg 1.69
Niacin, mcg 7095
Folic Acid (Folacin), mcg 101.4
Pantothenic Acid, mcg 3041
Biotin, mcg 29.7
Vitamin C (Ascorbic Acid), mg 60.8
Choline, mg 162.2
Inositol, mg 162.2
Amount Per Serving
Calcium, mg 709
Calcium, mEq 35.8
Phosphorus, mg 507
Magnesium, mg 40.5
Iron, mg 12.16
Zinc, mg 5.07
Manganese, mcg 33.8
Copper, mcg 608
Iodine, mcg 101
Selenium, mcg 14
Sodium, mg 297
Sodium, mEq 12.8
Potassium, mg 797
Potassium, mEq 20.3
Chloride, mg 439
Chloride, mEq 12.2

Similac Pro-Total Comfort® Powder

Similac Pro-Total Comfort 20 Cal/fl oz with 2'-FL Human Milk Oligosaccharide helps strengthen the immune system to be more like the breastfed infant than ever before.1,2,3 Easy-to-digest gentle protein and prebiotics. OptiGRO® is our exclusive blend of DHA, lutein and vitamin E: these important ingredients are found in breast milk.

  • DHA for brain and eye development.
  • Lutein to support eye health.
  • Vitamin E, an important nutrient to support developing cells.
Our exclusive formula has:
  • Partially hydrolyzed protein for easy digestion.
  • A unique blend of carbohydrates using two different absorption pathways to help maximize absorption and minimize malabsorption risks.
  • Calcium for strong bones - no palm olein oil.
  • Nucleotides to help support the immune system.
  • Prebiotics to help promote digestive health.
Gluten-free. Halal. Kosher made with dairy ingredients.

  • Not from human milk.
  • 1 Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.
  • 2 Schaller JP, et al. Pediatr Res. 2004;56(6):883-890.
  • 3 Buck RH, et al. Pediatr Res. 2004;56(6):891-900.


Unflavored Powder

Corn Maltodextrin, Whey Protein Hydrolysate, High Oleic Safflower Oil, Sugar, Soy Oil, Coconut Oil. Less than 2% of: Schizochytrium Sp. Oil*, M. Alpina Oil, 2'-Fucosyllactose, Short-chain Fructooligosaccharides§, Beta-Carotene, Lutein, Calcium Citrate, Potassium Phosphate, Calcium Phosphate, Salt, Magnesium Chloride, Ascorbic Acid, Choline Chloride, Inositol, Potassium Chloride, Sodium Citrate, Calcium Hydroxide, Potassium Citrate, Choline Bitartrate, Ferrous Sulfate, Taurine, Zinc Sulfate, Ascorbyl Palmitate, L-Carnitine, Niacinamide, Mixed Tocopherols, d-Alpha-Tocopheryl Acetate, Calcium Pantothenate, Copper Sulfate, Vitamin A Palmitate, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Manganese Sulfate, Potassium Iodide, Phylloquinone, Biotin, Sodium Selenate, Vitamin D3, Vitamin B12, Potassium Hydroxide, and Nucleotides (Adenosine 5'-Monophosphate, Cytidine 5'-Monophosphate, Disodium Guanosine 5'-Monophosphate, Disodium Uridine 5'-Monophosphate).
* Source of DHA.
Source of ARA.
2'-FL, a prebiotic like that found in breast milk.
§ Prebiotic


Consult physician prior to switching formulas.

Never use a microwave oven to warm formula. Serious burns can result.

Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by your baby's doctor.

Not for infants or children with galactosemia.

Please click "Accept Sale/Sharing and Targeted Advertising" to enable full site functionality.

At this time, we are experiencing problems with broken links on our site. As an interim solution, for full site functionality you must enable functional and advertising cookies. If you continue to opt-out of these cookies, some content on our site may not be viewable.

We use functional cookies to analyze your use of the site, improve performance and provide a better customer experience. We use advertising cookies to allow us, through certain data assigned and obtained from the user's device, to store or share with third parties information related to user's browsing activity in our website, in order to create an advertising profile and place relevant advertising in our website or those third parties websites. For more information about how Abbott uses cookies please see our Cookie Policy and Privacy Policy.

In order to accept functional and advertising cookies, please click "Enable Cookies" and then click "Accept Sale/Sharing and Targeted Advertising" to view the full site.

Learn more about cookies